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KMID : 0923620120120020066
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Immune Network
2012 Volume.12 No. 2 p.66 ~ p.69
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Chemotherapeutic Candidate Inducing Immunological Death of Human Tumor Cell Lines
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Oh Su-Jin
Ryu Chung-Kyu
Choi In-Hak
Baek So-Young
Lee Hyun-Ah
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Abstract
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The immunological death induction by EY-6 on the human tumor cell lines was screened. Human colon carcinoma (HCT15, HCT116), gastric carcinoma (MKN74, SNU668), and myeloma (KMS20, KMS26, KMS34) cells were died by EY-6 treatment with dose-dependent manner. CRT expression, a typical marker for the immunological death, was increased on the EY-6-treated colorectal and gastric cancer cells. Interestingly, the effects on the myeloma cell lines were complicated showing cell line dependent differential modulation. Cytokine secretion from the EY-6 treated tumor cells were dose and cell-dependent. IFN-? and IL-12 secretion was increased in the treated cells (200% to over 1000% of non-treated control), except HCT116, SNU668 and KMS26 cells which their secretion was declined by EY-6. Data suggest the potential of EY-6 as a new type of immuno-chemotherapeutics inducing tumor-specific cell death. Further studies are planned to confirm the efficacy of EY-6 including in vivo study.
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KEYWORD
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Indoledione derivative, Calreticulin, Immunological death, Human tumor cells
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